By Mengyi Lao, Xiaozhen Zhang, Hanshen Yang, Xueli Bai, and Tingbo Liang Molecular Medicine volume 28, Article number: 69 (2022) DOI: https://doi.org/10.1186/s10020-022-00492-7 Abstract Cancer is the leading cause of mortality worldwide. Regulator of calcineurin 1 (RCAN1), as a patent endogenous inhibitor of calcineurin, plays crucial roles in the pathogenesis of cancers. Except for hypopharyngeal and laryngopharynx...

By Zhong, QH., Zha, SW., Lau, A.T.Y. et al. Cancer Cell Int 22, 212 (2022). https://doi.org/10.1186/s12935-022-02619-6 Abstract Nuclear factor of activated T-cells, cytoplasmic 4 (NFATc4), a transcription factor of NFAT family, which is activated by Ca2+/calcineurin signaling. Recently, it is reported that aberrantly activated NFATc4 participated and modulated in the initiation, proliferation, invasion, and metastasis of various...

By Shouying Xu and Chao Tang Excerpt from article published in Frontiers in Cell and Developmental Biology, volume 10 (2022).  DOI=10.3389/fcell.2022.774291   Editor’s Highlights The Hedgehog (HH) signaling is one of the key agents that govern the precisely regulated developmental processes of multicellular organisms in vertebrates and invertebrates. Normal cholesterol concentrations are required for proper activation...

By Griffiths, S.C., Schwab, R.A., El Omari, K. et al. Excerpt from article published in Nature Communication, 12, 7171 (2021). https://doi.org/10.1038/s41467-021-27475-2 Editor’s Highlights The Hedgehog (HH) morphogen pathway fulfills crucial functions in growth and morphogenesis, whilst dysregulation leads to developmental disorders and cancer. Hedgehog-Interacting Protein (HHIP), the only reported secreted inhibitor of Sonic Hedgehog (SHH)...

By Ashley N. Sigafoos, Brooke D. Paradise, and Martin E. Fernandez-Zapico Excerpt from article published in Cancers (Basel). 2021 Jul; 13(14): 3410. doi: 10.3390/cancers13143410 Editor’s Highlights The Hedgehog/GLI (Hh/GLI) pathway plays a major role during development and it is commonly dysregulated in many diseases, including cancer. The Hh/GLI signaling pathway consists of a series of...